Similarly, there are also some drawbacks associated with oral esteroides which need to be addressed:
Efectos on the liver
The most common y highly experienced drawback of using oral esteroides is that it causes some extra stress on the liver.
Since everything that we take is broken down into nutrients, these nutrients travel from the stomach to the liver via the hepatic portal vein. después de that, the liver has the responsibility of removing all the toxic ingredients from the substance that has entered into the liver before its release into the circulatory system.
Since oral esteroides are considered toxic by the liver, the liver tries to remove all of its toxicity by converting them into an inactive state.
To help it get through the liver, a methyl group (a type of alkyl derived from methane) is added to the 17-alpha-carbon position. This modification is called 17-alpha-alkylation. This alteration in oral esteroides helps them to become highly active y bioavailable, but it increases the burden on the liver, which also increases toxicity levels. Even though the toxic Efectos of oral esteroides on the liver are high, most of the time they are understated.
Alcohol is the best example of this phenomenon. Alcohol causes more toxic Efectos on the liver as compared to oral esteroides. Since the liver can heal very quickly, if the oral esteroides are not overdosed or abused, then there is very little to no chance of experiencing any unwanted efectos secundarios.
Short half-life
Since oral esteroides carry very short half-life times in comparison to injectable esteroides, the individual must take the oral esteroides daily or sometimes twice a day to obtain the maximum benefits from the desired oral substance.
Negative impact on cholesterol levels
Another major drawback of oral esteroides is that they affect cholesterol levels negatively in a big way. It is very common for anabolic esteroides to negatively affect the lipid profile of the body.
Where oral esteroides are concerned, the negative impact on cholesterol levels is much higher compared to other drugs y injectable esteroides sold online. A significant reduction in high-density lipoproteins (HDL) y a significant rise in low-density lipoproteins (LDL) can occur, y this can cause atherosclerosis.
Due to these negative impacts of oral esteroides, it is always recommended to take oral esteroides for no more than 6 to 8 weeks at the beginning, midpoint, or at the end of your cycle (although this will be dependent on the desired outcomes of your cycle).
Reduced production of endogenous testosterone
One more disadvantage that all the esteroides (oral y injectable) have is that they obstruct the hypothalamus-pituitary-testicular axis (HPTA) y the production of endogenous testosterone.
Stacking
Since almost all esteroides are derivatives of androgenic testosterone, y these derivatives do not naturally appear in the body; testosterone must be stacked when oral esteroides are taken. This stacking is necessary to uphold the normal physiological operations of the body while following a cycle.
However, there is the opportunity of stacking with some commonly used y highly popular anabolic esteroides such as Anadrol or Dianabol, as they reduce the negative impact on the liver without reducing the overall effectiveness of the steroid.
